:root {
  --bg: #f5f8fc;
  --bg-deep: #071a2f;
  --bg-panel: rgba(8, 27, 48, 0.74);
  --card: #ffffff;
  --card-soft: #f8fbff;
  --ink: #102338;
  --muted: #587089;
  --line: #d8e3f0;
  --accent: #0e8c88;
  --accent-2: #1f4d8c;
  --accent-soft: #dff7f5;
  --hero-line: rgba(255, 255, 255, 0.12);
  --error: #b7424b;
  --ok: #1f8f66;
  --warn: #b97416;
  --shadow: 0 22px 60px rgba(10, 35, 66, 0.12);
}
* { box-sizing: border-box; }
body {
  margin: 0;
  font-family: "Avenir Next", "Segoe UI", "Helvetica Neue", Arial, sans-serif;
  color: var(--ink);
  background:
    radial-gradient(circle at top right, rgba(19, 140, 136, 0.14), transparent 32%),
    radial-gradient(circle at 15% 10%, rgba(31, 77, 140, 0.14), transparent 30%),
    linear-gradient(180deg, #eef4fb 0%, #f8fbff 28%, #f4f7fb 100%);
}
.page {
  width: min(1480px, calc(100vw - 40px));
  margin: 24px auto 72px;
}
.site-hero {
  position: relative;
  overflow: hidden;
  margin-bottom: 22px;
  padding: 24px 28px 28px;
  border-radius: 28px;
  background:
    radial-gradient(circle at top right, rgba(14, 140, 136, 0.25), transparent 28%),
    linear-gradient(135deg, #071a2f 0%, #102f55 45%, #0a5a66 100%);
  color: #f7fbff;
  box-shadow: 0 28px 70px rgba(8, 27, 48, 0.22);
}
.site-hero-index {
  padding-top: 22px;
  padding-bottom: 24px;
}
.site-hero::after {
  content: "";
  position: absolute;
  inset: auto -10% -45% 35%;
  height: 320px;
  background: radial-gradient(circle, rgba(255,255,255,0.12), transparent 58%);
  pointer-events: none;
}
.brand-bar {
  position: relative;
  z-index: 1;
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 24px;
  flex-wrap: nowrap;
  margin-bottom: 18px;
}
.site-hero-index .brand-bar {
  margin-bottom: 14px;
}
.brand-lockup {
  display: inline-flex;
  align-items: center;
  gap: 16px;
  color: inherit;
}
.brand-home-link,
.brand-kicker,
.brand-product {
  color: #fff !important;
  text-decoration: none !important;
}
.site-hero .brand-home-link,
.site-hero .brand-kicker,
.site-hero .brand-product,
.site-hero .brand-home-link:visited,
.site-hero .brand-kicker:visited,
.site-hero .brand-product:visited {
  color: #fff !important;
  text-decoration: none !important;
}
.brand-home-link {
  display: inline-flex;
  align-items: center;
}
.brand-home-link:hover,
.brand-kicker:hover,
.brand-product:hover {
  opacity: 0.86;
}
.brand-logo {
  display: block;
  height: 48px;
  width: auto;
}
.brand-copy {
  display: grid;
  gap: 2px;
}
.brand-actions {
  position: relative;
  z-index: 2;
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: 10px;
  justify-content: flex-end;
  margin-left: auto;
  max-width: min(820px, 68vw);
}
.brand-secondary-actions {
  display: inline-flex;
  align-items: center;
  justify-content: flex-end;
  gap: 8px;
  width: 100%;
}
.site-nav {
  display: inline-flex;
  align-items: center;
  justify-content: flex-end;
  flex-wrap: nowrap;
  gap: 6px;
  padding: 5px;
  border-radius: 999px;
  border: 1px solid rgba(255,255,255,0.14);
  background: rgba(255,255,255,0.08);
  backdrop-filter: blur(14px);
}
.site-nav a {
  display: inline-flex;
  align-items: center;
  min-height: 30px;
  padding: 7px 10px;
  border-radius: 999px;
  color: rgba(246, 251, 255, 0.82);
  text-decoration: none;
  font-weight: 700;
  font-size: 0.82rem;
}
.site-nav a:hover,
.site-nav a.active {
  color: #071a2f;
  background: rgba(255,255,255,0.9);
}
.species-switcher {
  display: inline-flex;
  align-items: center;
  gap: 4px;
  padding: 4px;
  border-radius: 999px;
  border: 1px solid rgba(255,255,255,0.16);
  background: rgba(255,255,255,0.08);
  backdrop-filter: blur(14px);
  white-space: nowrap;
}
.species-current,
.species-link {
  display: inline-flex;
  align-items: center;
  min-height: 28px;
  padding: 5px 10px;
  border-radius: 999px;
  font-size: 0.8rem;
  font-weight: 800;
  text-decoration: none;
}
.species-current {
  color: #071a2f;
  background: rgba(255,255,255,0.92);
}
.species-link {
  color: rgba(246, 251, 255, 0.84);
}
.species-link:hover {
  color: #071a2f;
  background: rgba(255,255,255,0.9);
}
.brand-kicker {
  font-size: 0.82rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: rgba(255,255,255,0.7);
}
.brand-product {
  font-size: 1.18rem;
  font-weight: 700;
  letter-spacing: 0.01em;
}
.hero-chip {
  display: inline-flex;
  align-items: center;
  padding: 8px 12px;
  border-radius: 999px;
  border: 1px solid rgba(255,255,255,0.16);
  background: rgba(255,255,255,0.08);
  color: #eef6ff;
  font-size: 0.84rem;
  white-space: nowrap;
  backdrop-filter: blur(16px);
}
.hero-chip-link {
  text-decoration: none;
}
.site-hero-doc .hero-copy h1 {
  max-width: 26ch;
}
.site-hero-doc .hero-grid {
  grid-template-columns: minmax(0, 1fr);
  gap: 0;
}
.hero-grid {
  position: relative;
  z-index: 1;
  display: grid;
  grid-template-columns: minmax(0, 1.45fr) minmax(300px, 0.55fr);
  gap: 24px;
  align-items: center;
}
.hero-copy h1 {
  margin: 0 0 12px;
  font-size: clamp(2rem, 3vw, 3.65rem);
  line-height: 1.02;
  letter-spacing: -0.03em;
  max-width: 16ch;
}
.site-hero-index .hero-copy h1 {
  max-width: 20ch;
}
.hero-copy p {
  margin: 0;
}
.eyebrow {
  margin: 0 0 10px;
  color: #91d7cf;
  font-size: 0.85rem;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}
.hero-text {
  max-width: 62ch;
  color: rgba(241, 247, 255, 0.82);
  font-size: 1.02rem;
  line-height: 1.6;
}
.hero-panel {
  padding: 18px;
  border-radius: 22px;
  border: 1px solid var(--hero-line);
  background: rgba(255,255,255,0.08);
  backdrop-filter: blur(14px);
}
.site-hero-index .hero-panel {
  padding: 14px;
}
.hero-actions-panel {
  display: flex;
  align-items: center;
  justify-content: flex-end;
}
.stats {
  display: grid;
  grid-template-columns: repeat(2, minmax(120px, 1fr));
  gap: 14px;
}
.stat, .card, .construct-card {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 22px;
  box-shadow: var(--shadow);
}
.partner-warning-card {
  margin: 0 0 18px;
  padding: 20px 22px;
  border-radius: 22px;
  border: 1px solid rgba(20, 120, 130, 0.28);
  background:
    linear-gradient(135deg, rgba(231, 249, 247, 0.96), rgba(240, 249, 255, 0.92)),
    #eefaf8;
  box-shadow: 0 18px 42px rgba(12, 84, 94, 0.1);
}
.partner-warning-card h2 {
  margin: 0 0 8px;
  color: #0b4f5a;
}
.partner-warning-card p {
  max-width: 100ch;
  margin: 0 0 10px;
  color: #153f48;
  line-height: 1.55;
}
.partner-warning-card p:last-child {
  margin-bottom: 0;
}
.warning-kicker {
  color: #0f7a7f !important;
  font-size: 0.78rem;
  font-weight: 800;
  letter-spacing: 0.14em;
  text-transform: uppercase;
}
.stat {
  padding: 14px 16px;
  text-align: center;
  background: rgba(255,255,255,0.1);
  border-color: rgba(255,255,255,0.1);
  box-shadow: none;
  color: #f7fbff;
}
.stat-primary {
  grid-column: 1 / -1;
  text-align: left;
  background: rgba(255,255,255,0.16);
}
.stat span {
  display: block;
  font-size: 1.65rem;
  font-weight: 700;
  color: #ffffff;
}
.stat label {
  color: rgba(241,247,255,0.72);
  font-size: 0.88rem;
}
.status-strip {
  display: flex;
  flex-wrap: nowrap;
  gap: 6px;
  margin-top: 10px;
  white-space: nowrap;
}
.status-strip span {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  flex: 1 1 0;
  min-width: 0;
  min-height: 28px;
  padding: 6px 8px;
  border-radius: 999px;
  background: rgba(255,255,255,0.1);
  border: 1px solid rgba(255,255,255,0.12);
  color: rgba(241,247,255,0.82);
  font-size: clamp(0.74rem, 0.82vw, 0.85rem);
  font-weight: 700;
  overflow: hidden;
  text-overflow: ellipsis;
}
.controls {
  display: flex;
  gap: 12px;
  margin-bottom: 12px;
  flex-wrap: wrap;
}
.controls input, .controls select, .controls button {
  border: 1px solid var(--line);
  background: rgba(255,255,255,0.82);
  border-radius: 999px;
  padding: 12px 16px;
  font: inherit;
  color: var(--ink);
  box-shadow: 0 8px 18px rgba(16, 35, 56, 0.05);
}
.controls input { flex: 1; }
.controls button { cursor: pointer; }
.disease-cell {
  display: grid;
  gap: 3px;
  min-width: 180px;
}
.muted-small {
  color: var(--muted);
  font-size: 0.82rem;
}
.sort-summary {
  display: inline-flex;
  align-items: center;
  padding: 12px 16px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: rgba(255,255,255,0.82);
  color: var(--muted);
  font-weight: 600;
  box-shadow: 0 8px 18px rgba(16, 35, 56, 0.05);
}
.pagination-bar {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  align-items: center;
  justify-content: flex-end;
  margin: -4px 0 16px;
}
.page-size-control {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  margin-right: auto;
  padding: 6px 8px 6px 12px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: rgba(255,255,255,0.82);
  color: var(--muted);
  font-weight: 700;
  box-shadow: 0 8px 18px rgba(16, 35, 56, 0.05);
}
.page-size-control select {
  min-height: 32px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: #ffffff;
  color: var(--ink);
  font: inherit;
  font-weight: 700;
  padding: 4px 26px 4px 10px;
}
.pagination-summary {
  min-width: 220px;
  color: var(--muted);
  font-weight: 700;
  text-align: center;
}
.card {
  padding: 22px;
  margin-bottom: 18px;
  overflow: auto;
  background: linear-gradient(180deg, #ffffff 0%, #fbfdff 100%);
}
.table-card {
  padding: 8px 12px 12px;
}
.stack {
  display: grid;
  grid-template-columns: 1fr;
  gap: 18px;
}
.grid.two {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 18px;
}
.doc-layout {
  display: grid;
  gap: 18px;
}
.doc-grid,
.download-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 18px;
}
.calculator-layout {
  display: grid;
  grid-template-columns: minmax(0, 1.18fr) minmax(320px, 0.82fr);
  gap: 18px;
  align-items: start;
}
.calculator-hero-panel {
  display: grid;
  gap: 10px;
  align-self: stretch;
  align-content: center;
  color: rgba(241, 247, 255, 0.84);
  font-weight: 700;
}
.calculator-card {
  overflow: visible;
}
.calculator-card-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 14px;
  margin-bottom: 12px;
}
.calc-status {
  display: inline-flex;
  align-items: center;
  min-height: 32px;
  padding: 6px 11px;
  border-radius: 999px;
  font-size: 0.82rem;
  font-weight: 800;
  white-space: nowrap;
}
.calc-status.waiting {
  background: #fff4d7;
  color: #8a5b00;
}
.calc-status.ready {
  background: #e8f8f1;
  color: var(--ok);
}
.calculator-form {
  display: grid;
  border: 1px solid var(--line);
  border-radius: 16px;
  overflow: hidden;
  background: #fff;
}
.calculator-row {
  display: grid;
  grid-template-columns: minmax(190px, 0.95fr) minmax(160px, 1fr) minmax(118px, 0.5fr);
  gap: 12px;
  align-items: center;
  min-height: 78px;
  padding: 14px;
  border-bottom: 1px solid var(--line);
}
.calculator-row:last-child {
  border-bottom: 0;
}
.calculator-row label {
  display: grid;
  gap: 4px;
  color: var(--ink);
  font-weight: 800;
  line-height: 1.25;
}
.calculator-row label span {
  color: var(--muted);
  font-size: 0.78rem;
  font-weight: 600;
  line-height: 1.35;
}
.calculator-row label .required-tag {
  display: inline-flex;
  width: max-content;
  padding: 2px 7px;
  border-radius: 999px;
  background: var(--accent-soft);
  color: var(--accent);
  font-size: 0.7rem;
  font-weight: 900;
  text-transform: uppercase;
  letter-spacing: 0.06em;
}
.calculator-row input,
.calculator-row select {
  width: 100%;
  min-height: 42px;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: #fff;
  color: var(--ink);
  font: inherit;
  font-size: 0.95rem;
}
.calculator-row input {
  padding: 9px 11px;
  font-variant-numeric: tabular-nums;
}
.calculator-row select {
  padding: 9px 10px;
  cursor: pointer;
}
.calculator-row select:disabled {
  color: var(--muted);
  cursor: default;
  background: #f5f8fc;
}
.calculator-row input.calculated {
  background: #f5fbff;
  color: #24435f;
}
.calculator-row input.user-set {
  border-color: var(--accent);
  box-shadow: inset 0 0 0 1px rgba(14, 140, 136, 0.22);
}
.calculator-actions {
  display: flex;
  justify-content: flex-end;
  gap: 10px;
  flex-wrap: wrap;
  margin-top: 14px;
}
.calc-message {
  min-height: 92px;
  margin-bottom: 16px;
  padding: 13px 14px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: #f6faff;
  color: var(--muted);
  line-height: 1.5;
}
.calc-message strong {
  color: var(--ink);
}
.calc-message.error {
  border-color: #e1a4aa;
  background: #fff2f3;
  color: #8d313a;
}
.calc-message.ready {
  border-color: #a5ddc8;
  background: #f1fbf6;
  color: #1f6d50;
}
.calculator-facts {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 0 14px;
  margin: 0 0 16px;
}
.calculator-facts dt,
.calculator-facts dd {
  margin: 0;
  padding: 10px 0;
  border-bottom: 1px solid var(--line);
}
.calculator-facts dt {
  color: var(--muted);
  font-weight: 700;
}
.calculator-facts dd {
  text-align: right;
  font-weight: 800;
  font-variant-numeric: tabular-nums;
}
.calculator-notes {
  font-size: 0.92rem;
}
.doc-card {
  overflow: visible;
}
.doc-card p {
  margin: 0 0 12px;
  color: var(--muted);
  line-height: 1.65;
}
.doc-card p:last-child {
  margin-bottom: 0;
}
.doc-list {
  margin: 0;
  padding-left: 22px;
  color: var(--muted);
  line-height: 1.7;
}
.doc-list li + li {
  margin-top: 8px;
}
.code-block {
  overflow: auto;
  margin: 12px 0;
  padding: 14px;
  border-radius: 14px;
  background: #081b30;
  color: #eef7ff;
  font-size: 0.9rem;
  line-height: 1.5;
}
table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.95rem;
}
th, td {
  text-align: left;
  padding: 10px 12px;
  border-bottom: 1px solid var(--line);
  vertical-align: top;
}
th {
  position: sticky;
  top: 0;
  background: #f6faff;
  color: #26435f;
}
.sort-header {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  padding: 0;
  border: 0;
  background: transparent;
  color: inherit;
  font: inherit;
  font-weight: 700;
  cursor: pointer;
}
.sort-header .sort-arrow {
  color: var(--muted);
  font-size: 0.9em;
}
.sort-header.active {
  color: var(--accent);
}
.sort-header.active .sort-arrow {
  color: var(--accent);
}
.status {
  display: inline-block;
  padding: 4px 10px;
  border-radius: 999px;
  font-size: 0.82rem;
  font-weight: 700;
}
.status.ok, .status.skipped_existing { background: #e8f8f1; color: var(--ok); }
.status.pending, .status.running { background: #fff4d7; color: #8a5b00; }
.status.error { background: #fdebed; color: var(--error); }
.structure-badge {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 46px;
  padding: 4px 10px;
  border-radius: 999px;
  font-size: 0.78rem;
  font-weight: 800;
  letter-spacing: 0.02em;
}
.structure-badge.yes {
  background: rgba(15, 154, 112, 0.14);
  color: #0f6c53;
}
.structure-badge.no {
  background: rgba(120, 137, 160, 0.14);
  color: #5a6c80;
}
.link-group { display: flex; gap: 10px; flex-wrap: wrap; align-items: center; }
.link-group-wrap {
  margin-top: 18px;
}
.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  text-decoration: none;
  color: white;
  background: linear-gradient(135deg, var(--accent), var(--accent-2));
  border: 0;
  padding: 11px 16px;
  border-radius: 999px;
  font-weight: 700;
  font: inherit;
  box-shadow: 0 12px 28px rgba(15, 93, 124, 0.28);
  cursor: pointer;
}
.button:disabled,
.mini-button:disabled {
  opacity: 0.62;
  cursor: progress;
}
.refresh-control {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  max-width: 260px;
}
.refresh-target-button.compact {
  padding: 7px 10px;
  font-size: 0.82rem;
  box-shadow: none;
}
.refresh-target-button.link-style {
  background: transparent;
  color: var(--accent);
  padding: 0;
  border-radius: 0;
  box-shadow: none;
  font-weight: 800;
  text-decoration: none;
}
.refresh-target-button.link-style:hover {
  text-decoration: underline;
}
.refresh-target-status {
  color: var(--muted);
  font-size: 0.8rem;
  line-height: 1.2;
}
.mini-button {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  border: 1px solid var(--line);
  background: #fff;
  color: var(--accent);
  padding: 6px 10px;
  border-radius: 999px;
  font: inherit;
  font-size: 0.88rem;
  cursor: pointer;
}
.mini-button.active {
  background: var(--accent);
  border-color: var(--accent);
  color: #fff;
}
.mini-button:disabled {
  cursor: not-allowed;
  opacity: 0.48;
}
.construct-actions {
  margin: 4px 0 14px;
}
.view-3d-btn {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  border: 1px solid var(--accent);
  background: var(--accent);
  color: #fff;
  padding: 9px 16px;
  border-radius: 999px;
  font: inherit;
  font-size: 0.92rem;
  font-weight: 600;
  line-height: 1;
  cursor: pointer;
  box-shadow: 0 1px 3px rgba(0, 0, 0, 0.16);
  transition: background 0.15s ease, box-shadow 0.15s ease, transform 0.04s ease;
}
.view-3d-btn:hover {
  background: var(--accent-2);
  border-color: var(--accent-2);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.22);
}
.view-3d-btn:active {
  transform: translateY(1px);
}
.view-3d-btn:focus-visible {
  outline: 2px solid var(--accent-2);
  outline-offset: 2px;
}
.view-3d-btn svg {
  width: 17px;
  height: 17px;
  flex: none;
}
.view-3d-btn--compact {
  padding: 6px 12px;
  font-size: 0.84rem;
  box-shadow: none;
}
.view-3d-btn--compact svg {
  width: 15px;
  height: 15px;
}
.button-row {
  display: inline-flex;
  flex-wrap: wrap;
  gap: 8px;
}
.inline-link {
  display: inline-flex;
  align-items: center;
  gap: 4px;
  margin-right: 8px;
  color: var(--accent);
  font-weight: 700;
  text-decoration: none;
}
.inline-link:hover {
  text-decoration: underline;
}
.muted {
  color: var(--muted);
}
.meta {
  display: grid;
  grid-template-columns: max-content 1fr;
  gap: 10px 14px;
  margin: 0;
}
.meta dt { font-weight: 700; }
.meta dd { margin: 0; color: var(--muted); }
.card h2 {
  margin: 0 0 16px;
  font-size: 1.08rem;
  letter-spacing: -0.01em;
}
.af3-notice {
  display: flex;
  align-items: flex-start;
  gap: 12px;
  margin: 0 0 16px;
  padding: 11px 15px;
  background: #fff7e6;
  border: 1px solid #e6c46a;
  border-left: 4px solid #d49f3f;
  border-radius: 10px;
  font-size: 0.9rem;
  line-height: 1.45;
  color: #5b4413;
}
.af3-notice-badge {
  flex: none;
  align-self: center;
  padding: 3px 10px;
  border-radius: 999px;
  background: #d49f3f;
  color: #fff;
  font-size: 0.74rem;
  font-weight: 700;
  letter-spacing: 0.02em;
  white-space: nowrap;
}
.af3-notice a {
  color: #9a6b12;
  font-weight: 600;
  text-decoration: underline;
}
.viewer-layout {
  display: grid;
  grid-template-columns: minmax(340px, 0.9fr) minmax(320px, 1.1fr);
  gap: 18px;
}
.viewer-panel, .sequence-panel {
  display: grid;
  gap: 12px;
}
.viewer-toolbar {
  display: flex;
  gap: 10px;
  align-items: center;
  flex-wrap: wrap;
}
.viewer-note, .viewer-info {
  color: var(--muted);
}
.structure-viewer {
  position: relative;
  width: 100%;
  min-height: 420px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: #fff;
  overflow: hidden;
}
.interactive-plots {
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(0, 1fr);
  gap: 18px;
  margin-top: 8px;
}
.topology-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 8px 12px;
  margin-top: 8px;
  color: var(--muted);
  font-size: 0.82rem;
}
.topology-legend-item {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  white-space: nowrap;
}
.topology-swatch {
  display: inline-block;
  width: 12px;
  height: 12px;
  border-radius: 999px;
  border: 1px solid rgba(0, 0, 0, 0.12);
}
.gpcr-swatch {
  background: #1f1f1f;
  border-radius: 2px;
}
.selection-live-card {
  margin-top: 18px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: #fff;
}
.selection-live-header {
  display: flex;
  justify-content: space-between;
  gap: 12px;
  align-items: center;
  flex-wrap: wrap;
  margin-bottom: 10px;
}
.selection-live-header h3 {
  margin: 0;
}
.selection-table-wrap {
  overflow: auto;
}
.selection-warnings {
  margin: 10px 0 14px;
}
.selection-warning-block {
  padding: 10px 12px;
  border-radius: 12px;
  border: 1px solid var(--line);
  background: #fcfaf6;
  margin-bottom: 10px;
}
.selection-warning-block.cysteine {
  border-color: #d5b26b;
  background: #fff7e6;
}
.selection-warning-block.furin {
  border-color: #d39a9a;
  background: #fff1f1;
}
.selection-warning-block strong {
  display: block;
  margin-bottom: 6px;
}
.selection-warning-block ul {
  margin: 0;
  padding-left: 18px;
}
.mutation-controls {
  display: grid;
  gap: 8px;
  margin-top: 12px;
  padding: 12px;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: #fcfdff;
}
.mutation-checkboxes {
  display: flex;
  flex-wrap: wrap;
  gap: 10px 14px;
}
.mutation-checkbox {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font: 600 0.88rem/1.2 ui-sans-serif, system-ui, sans-serif;
  color: #24435f;
}
.mutation-checkbox input {
  margin: 0;
}
.selection-tsv {
  width: 100%;
  min-height: 110px;
  margin-top: 12px;
  padding: 10px 12px;
  border: 1px solid var(--line);
  border-radius: 12px;
  font: 0.82rem/1.4 ui-monospace, SFMono-Regular, Menlo, monospace;
  background: #fcfaf6;
  color: var(--ink);
}
.plot-card {
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: #fff;
}
.plot-card-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 12px;
  flex-wrap: wrap;
  margin-bottom: 12px;
}
.plot-card h3 {
  margin: 0;
}
.plot-controls {
  display: flex;
  gap: 8px;
  flex-wrap: wrap;
}
.plot-svg {
  width: 100%;
  height: 240px;
  display: block;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: white;
  cursor: crosshair;
}
.pae-canvas {
  width: 100%;
  max-width: 520px;
  aspect-ratio: 1 / 1;
  display: block;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: white;
  cursor: crosshair;
}
.sequence-header {
  display: flex;
  flex-wrap: wrap;
  justify-content: space-between;
  gap: 8px;
  color: var(--muted);
}
.sequence-viewer {
  border: 1px solid var(--line);
  border-radius: 16px;
  background: #fff;
  padding: 12px;
  max-height: 480px;
  overflow: auto;
}
.sequence-row {
  display: grid;
  grid-template-columns: 48px 1fr;
  gap: 10px;
  align-items: start;
  margin-bottom: 8px;
}
.sequence-index {
  color: var(--muted);
  font: 600 0.82rem/1.8 ui-monospace, SFMono-Regular, Menlo, monospace;
  text-align: right;
}
.sequence-residues {
  display: flex;
  flex-wrap: wrap;
  gap: 2px;
}
.residue {
  border: 0;
  background: transparent;
  color: #3e2f1c;
  padding: 2px 3px;
  border-radius: 6px;
  font: 600 0.8rem/1 ui-monospace, SFMono-Regular, Menlo, monospace;
  cursor: pointer;
}
.residue:hover {
  background: #f7efe3;
}
.residue.ecto-residue {
  background: #eef6ff;
}
.residue.active-range {
  background: #dbeadf;
  color: #1f5c3e;
}
.residue.active-residue {
  background: #fce7ea;
  color: #a61e2e;
}
.construct-list { display: grid; gap: 16px; }
.construct-card {
  display: grid;
  grid-template-columns: 1fr;
  gap: 18px;
  padding: 18px;
  background: linear-gradient(180deg, #ffffff 0%, #f9fcff 100%);
}
.construct-card h3 { margin-top: 0; }
.construct-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 12px 18px;
}
.construct-export-card {
  display: grid;
  gap: 12px;
  margin: 12px 0 16px;
  padding: 14px;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: #fcfdff;
}
.construct-export-card h4 {
  margin: 0;
}
.export-box-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 12px;
}
.export-label {
  display: inline-block;
  margin-bottom: 6px;
  font-weight: 700;
  color: var(--muted);
}
.construct-export-box {
  min-height: 132px;
  margin-top: 0;
}
.construct-sequence-table code.sequence {
  max-height: 96px;
  overflow: auto;
}
.construct-grid h4 { margin-bottom: 6px; }
.construct-card ul { margin: 0; padding-left: 18px; }
.construct-images {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
  align-content: start;
}
.construct-images img {
  width: 100%;
  border-radius: 12px;
  border: 1px solid var(--line);
  background: white;
}
.alignment-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 10px 16px;
  margin: 8px 0 10px;
  color: var(--muted);
  font-size: 0.88rem;
}
.alignment-legend {
  display: inline-flex;
  align-items: center;
  gap: 7px;
  margin: 0 0 8px;
  color: var(--muted);
  font-size: 0.82rem;
}
.alignment-residue {
  display: inline-block;
  width: 1ch;
  min-width: 1ch;
  text-align: center;
  font: inherit;
  letter-spacing: 0;
  box-sizing: content-box;
}
.alignment-surface-ecto {
  border-radius: 3px;
  background: #f7c948;
  color: #2f2300;
  font-weight: 800;
}
.alignment-block {
  margin: 0;
  padding: 10px 12px;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: #fcfaf6;
  font: 0.8rem/1.45 ui-monospace, SFMono-Regular, Menlo, monospace;
  letter-spacing: 0;
  tab-size: 4;
  white-space: pre;
  overflow: auto;
}
.alignment-block * {
  font: inherit;
  letter-spacing: inherit;
}
.hit-description {
  margin-top: 4px;
  max-width: 36ch;
}
.cross-reactivity-scroll details summary {
  cursor: pointer;
  font-weight: 700;
}
code.sequence {
  display: inline-block;
  white-space: pre-wrap;
  word-break: break-word;
  font-size: 0.86rem;
}
.matrix-wrap {
  overflow: auto;
  margin-top: 14px;
}
.matrix-wrap table {
  min-width: max-content;
}
.matrix-wrap tbody th {
  position: sticky;
  left: 0;
  z-index: 1;
  background: #f6faff;
}
.matrix-cell {
  text-align: center;
  white-space: nowrap;
  min-width: 84px;
}
.matrix-cell-empty {
  background: #f9fbfe;
  color: #94a6b8;
  box-shadow: inset 0 0 0 1px #e4edf5;
}
.table-scroll {
  overflow: auto;
}
.cross-reactivity-scroll {
  max-height: 420px;
}
.site-footer {
  width: 100%;
  max-width: 100%;
  margin: 34px 0 0;
  padding: 26px;
  border: 1px solid var(--line);
  border-radius: 24px;
  background:
    linear-gradient(180deg, rgba(255,255,255,0.92), rgba(248,251,255,0.96)),
    radial-gradient(circle at top right, rgba(14, 140, 136, 0.1), transparent 38%);
  box-shadow: 0 18px 50px rgba(10, 35, 66, 0.08);
  overflow: hidden;
}
.footer-grid {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 24px;
  flex-wrap: wrap;
}
.footer-brand {
  display: flex;
  align-items: center;
  gap: 16px;
  max-width: 620px;
}
.footer-logo-link {
  display: inline-flex;
  align-items: center;
  flex: 0 0 auto;
}
.footer-logo-link:hover {
  opacity: 0.82;
}
.footer-logo {
  display: block;
  height: 42px;
  width: auto;
}
.footer-brand strong {
  display: block;
  font-size: 1.08rem;
  letter-spacing: -0.01em;
}
.footer-brand p {
  margin: 4px 0 0;
  color: var(--muted);
  line-height: 1.45;
}
.footer-links {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  justify-content: flex-end;
}
.footer-links a {
  display: inline-flex;
  align-items: center;
  min-height: 34px;
  padding: 8px 12px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: #ffffff;
  color: var(--accent-2);
  font-weight: 700;
  text-decoration: none;
}
.footer-links a:hover {
  border-color: rgba(14, 140, 136, 0.32);
  color: var(--accent);
}
.footer-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 10px 18px;
  margin-top: 20px;
  padding-top: 16px;
  border-top: 1px solid var(--line);
  color: var(--muted);
  font-size: 0.9rem;
}
.footer-meta a {
  color: var(--accent-2);
  text-decoration: none;
  font-weight: 700;
}
.section-note {
  margin: 0 0 10px;
  color: var(--muted);
}
.index-default-note {
  margin: -2px 0 18px;
  padding: 10px 14px;
  border: 1px solid rgba(14, 140, 136, 0.18);
  border-radius: 14px;
  background: rgba(14, 140, 136, 0.06);
}
a { color: var(--accent-2); }
input::placeholder {
  color: #7d93a8;
}
select, input, button, textarea {
  outline: none;
}
select:focus, input:focus, button:focus, textarea:focus, .residue:focus {
  box-shadow: 0 0 0 3px rgba(14, 140, 136, 0.18);
}
@media (max-width: 980px) {
  .hero-grid, .grid.two, .stack, .construct-card, .viewer-layout, .doc-grid, .download-grid, .calculator-layout { grid-template-columns: 1fr; display: grid; }
  .calculator-row { grid-template-columns: 1fr; min-height: 0; }
  .calculator-card-header { align-items: flex-start; flex-direction: column; }
  .calc-status { white-space: normal; }
  .interactive-plots { grid-template-columns: 1fr; }
  .construct-images { grid-template-columns: 1fr; }
  .stats { grid-template-columns: repeat(2, 1fr); }
  .stat-primary { grid-column: span 2; text-align: center; }
  .footer-brand { align-items: flex-start; }
  .footer-links { justify-content: flex-start; }
  .site-hero { padding: 22px 20px 24px; }
  .brand-bar { flex-wrap: wrap; align-items: center; }
  .brand-actions { align-items: flex-start; justify-content: flex-start; max-width: 100%; width: 100%; }
  .brand-secondary-actions { justify-content: flex-start; }
  .site-nav { justify-content: flex-start; flex-wrap: wrap; border-radius: 18px; }
  .hero-chip { display: none; }
  .brand-logo { height: 40px; }
  .page { width: min(1480px, calc(100vw - 24px)); }
}